Publications
Our patents
Some of the work we’ve been involved in
Yáñez-Ruiz, D.R. (2012)
Technological platform to develop nutritional additives to reduce methane emissions from ruminants (SMEthane)
Agencia Estatal Consejo Superior de Investigaciones Cientificas, Spain
Newbold, J. (2010)
Ruminant nutrition regimes to reduce methane & nitrogen emissions
Aberystwyth University
Some of our peer-reviewed publications
Synthetic Chemistry
Baker, A., Graz, M., Saunders, R., Evans, G., Piotti, I. and Wirth, T., 2015
Flow Alkylation of Thiols, phenols and Amines Using a heterogenous Base in a packed-Bed Reactor
J.Flow.Chem, 5(2):65-68.
Baker, A., Graz, M., Saunders, R., Evans, G., Kaul, S. and Wirth, T. (2013)
Flow Synthesis of Symmetrical di- and Trisulfides using phase-Transfer Catalysis
J. Flow Chem, 3:118-121.
Veterinary interventions
Williams, C., Lloyd, D., Kolarich, D., Alagesan, K., Duchêne, M., Cable, J., Williams, dD. and Leitsch, D. (2012)
Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds
Veterinary parasitology: 190(1-2):62-73
Milet, C.O., Lloyd, D., Williams, C., Williams, D., Evans, G., Saunders, R. and Cable,. J. (2011)
Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens
Experimental parasitology: 127(2):490-9
Rumen microbiology
Hart, K., Yáñez-Ruiz, D.R., Duval, S.M., Mcewan, N.R. and Newbold, C.J. (2008)
Plant extracts to manipulate rumen fermentation
Anim. Feed Sci.Technol, 11, 147 (1-3), doi:10.1016/j.anifeedsci.2007.09.007.
Some of our conference presentations
Assay development for Quorum Sensing
Williams, D., Oldham, H. and Graz, M. (2017) 
Development of an in-house in vitro Quorum Sensing Inhibitor detection assay and confirmation of the Quorum Sensing Inhibition activity of NX-AS-401,
40th European Cystic Fibrosis Conference, Seville, Spain (Poster)
Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis
Graz, M., Walker, S., Alderson, D., Morris, J. and Graz, H. (2017)
Exploring economic value in treating Pseudomonas aeruginosa infections in cystic fibrosis
– early modeling to inform product development”, 22nd Annual ISPOR Congress, Boston, USA (Poster)
Mulkern, A., Oyama, L, Graz, M., Evans, G., Williams, D. and Huws, S. (2017)
Potential therapeutic uses of novel antimicrobial peptides isolated from the rumen microbiome against Pseudomonas aeruginosa,
SDRI Conference, Brisbane, Australia (Poster)
Bricio-Morena, L., Waters, B., Neil, D., Evans, G., Graz, M., Fothergill, J. and Kadioglu, A. (2017)
Ajoene, a novel therapeutic that shows enhanced activity in in vivo and in vitro models of Pseudomonas aeruginosa infection,
SDRI Conference, Brisbane, Australia (Poster)
Graz, M., Williams, D., Bricio-Moreno, L., Fothergill, J. and Kadioglu, A. (2017)
Effect of (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide in in vivo and in vitro Models of Pseudomonas aeruginosa Infection
ASM/ESCMID, Boston, MA (Poster)
Williams, D., Sykes, L., Bricio-Moreno, L., Fothergill, J., Kadioglu, A., Oldham, H., Clark, S. and Graz, M. (2017)
NX-AS-401: A quorum sensing inhibitor that enhances the effect of P.aeruginosa in vitro and in vivo
North American Cystic Fibrosis Conference, Indianapolis (poster)
Antimicrobial effects of plant extracts
Martí, G., Evans, G., Jones, L., Viadel, B., Ruiz, B., Gallego, E. and Graz, M. (2017)
Bioaccessability of organosulphur conpounds from Allium sativum
ICMAN-IUPHAR, Aberdeen, UK (Poster)
Whatmough, A., Williams, D., Evans, G. and Graz, M. (2017)
Identification of a novel synergistic combination of natural extracts for infection control in diabetic ulcers
ICMAN-IUPHAR, Aberdeen, UK (Poster)
Peng, L.V., De Costa P., Chong P.W., Graz M. and Jee J.M. (2014)
Antimicrobial Effects of a Proprietary Standardised Garlic Extract iQ-AS-105: A broad spectrum activity on Gram Negative, Gram Positive and Fungal Microorganisms
Proceedings of the Antibiotic Alternatives for the New millennium, London, UK. (Poster)
Williams R.O., Day, M., Lloyd, D., Wirth, T., Jones, L., Evans, G., De Costa, P. and Graz, M. (2014)
Inhibitory Effects of Garlic Metabolites on Clostridium difficile
Proceedings of the Antibiotic Alternatives for the New millennium, London, UK. (Poster)
Synthetic chemistry
Baker, A., Graz, M., Saunders, R., Evans, G. and Wirth, T. (2013)
Synthesis of Di- and Trisulfides using Flow Reactors
Presented at the 12th International Conference on Selenium and Tellurium, Cardiff, UK (poster)
Baker, A., Graz, M., Saunders, R., Evans, G. and Wirth, T. (2013)
Synthesis of Di- and Trisulfides using Flow Reactors
Presented at the 2nd SCi/RSC Symposium on Continuous Processing and Flow Chemistry, Horsham, UK
Bioanalysis
Thabit Jones, A., Graz, M and Oldham, H (2017)
Quantitative analysis of an oil based natural compound extracted from plasma
ICMAN-IUPHAR, Aberdeen, UK (Poster and oral presentation)
Drug development studies
Oldham, H. (2017)
Drug Development with natural products – A journey
ICMAN-IUPHAR, Aberdeen, UK 
Oldham, H. (2017)
Drug metabolism studies with natural products – A journey
46th Drug Metabolism Discussion Group Open Meeting, Cambridge, UK
Oldham, H. (2017)
P1b - Drug metabolism studies with natural products
46th Drug Metabolism Discussion Group Open Meeting, Cambridge, UK
Mootral
Graz, M., Vrancken, H., Riede, O. and Brandsma, M. (2017)
The effect of a blend of natural compounds (NX-RH-201) on the quality of milk produced ona cpmmercial farm under normal operational conditions
International Dairy Federation Summit, Ireland (poster)

Publications
Our patents
Process for the preparation of Ajoene (Patent WO 2010100486 A 3) 2010
Process for the production of Allicin (Patent WO 2003004668 A 1) 2003
Extraction method for Azadirachtin (Patent WO 2002032907 A 1) 2002
Some of the work we’ve been involved in
Yáñez-Ruiz, D.R. (2012)
Technological platform to develop nutritional additives to reduce methane emissions from ruminants (SMEthane)
Agencia Estatal Consejo Superior de Investigaciones Cientificas, Spain
Newbold, J. (2010)
Ruminant nutrition regimes to reduce methane & nitrogen emissions
Aberystwyth University
Some of our peer-reviewed publications
Synthetic Chemistry
Baker, A., Graz, M., Saunders, R., Evans, G., Piotti, I. and Wirth, T., 2015
Flow Alkylation of Thiols, phenols and Amines Using a heterogenous Base in a packed-Bed Reactor
J.Flow.Chem, 5(2):65-68.
Baker, A., Graz, M., Saunders, R., Evans, G., Kaul, S. and Wirth, T. (2013)
Flow Synthesis of Symmetrical di- and Trisulfides using phase-Transfer Catalysis
J. Flow Chem, 3:118-121.
Veterinary interventions
Williams, C., Lloyd, D., Kolarich, D., Alagesan, K., Duchêne, M., Cable, J., Williams, dD. and Leitsch, D. (2012)
Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds
Veterinary parasitology: 190(1-2):62-73
Milet, C.O., Lloyd, D., Williams, C., Williams, D., Evans, G., Saunders, R. and Cable,. J. (2011)
Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens
Experimental parasitology: 127(2):490-9
Rumen microbiology
Hart, K., Yáñez-Ruiz, D.R., Duval, S.M., Mcewan, N.R. and Newbold, C.J. (2008)
Plant extracts to manipulate rumen fermentation
Anim. Feed Sci.Technol, 11, 147 (1-3), doi:10.1016/j.anifeedsci.2007.09.007.
Some of our conference presentations
Assay development for Quorum Sensing
Williams, D., Oldham, H. and Graz, M. (2017) 
Development of an in-house in vitro Quorum Sensing Inhibitor detection assay and confirmation of the Quorum Sensing Inhibition activity of NX-AS-401,
40th European Cystic Fibrosis Conference, Seville, Spain (Poster)
Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis
Graz, M., Walker, S., Alderson, D., Morris, J. and Graz, H. (2017)
Exploring economic value in treating Pseudomonas aeruginosa infections in cystic fibrosis
– early modeling to inform product development”, 22nd Annual ISPOR Congress, Boston, USA (Poster)
Mulkern, A., Oyama, L, Graz, M., Evans, G., Williams, D. and Huws, S. (2017)
Potential therapeutic uses of novel antimicrobial peptides isolated from the rumen microbiome against Pseudomonas aeruginosa,
SDRI Conference, Brisbane, Australia (Poster)
Bricio-Morena, L., Waters, B., Neil, D., Evans, G., Graz, M., Fothergill, J. and Kadioglu, A. (2017)
Ajoene, a novel therapeutic that shows enhanced activity in in vivo and in vitro models of Pseudomonas aeruginosa infection,
SDRI Conference, Brisbane, Australia (Poster)
Graz, M., Williams, D., Bricio-Moreno, L., Fothergill, J. and Kadioglu, A. (2017)
Effect of (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide in in vivo and in vitro Models of Pseudomonas aeruginosa Infection
ASM/ESCMID, Boston, MA (Poster)
Williams, D., Sykes, L., Bricio-Moreno, L., Fothergill, J., Kadioglu, A., Oldham, H., Clark, S. and Graz, M. (2017)
NX-AS-401: A quorum sensing inhibitor that enhances the effect of P.aeruginosa in vitro and in vivo
North American Cystic Fibrosis Conference, Indianapolis (poster)
Antimicrobial effects of plant extracts
Martí, G., Evans, G., Jones, L., Viadel, B., Ruiz, B., Gallego, E. and Graz, M. (2017)
Bioaccessability of organosulphur conpounds from Allium sativum
ICMAN-IUPHAR, Aberdeen, UK (Poster)
Whatmough, A., Williams, D., Evans, G. and Graz, M. (2017)
Identification of a novel synergistic combination of natural extracts for infection control in diabetic ulcers
ICMAN-IUPHAR, Aberdeen, UK (Poster)
Peng, L.V., De Costa P., Chong P.W., Graz M. and Jee J.M. (2014)
Antimicrobial Effects of a Proprietary Standardised Garlic Extract iQ-AS-105: A broad spectrum activity on Gram Negative, Gram Positive and Fungal Microorganisms
Proceedings of the Antibiotic Alternatives for the New millennium, London, UK. (Poster)
Williams R.O., Day, M., Lloyd, D., Wirth, T., Jones, L., Evans, G., De Costa, P. and Graz, M. (2014)
Inhibitory Effects of Garlic Metabolites on Clostridium difficile
Proceedings of the Antibiotic Alternatives for the New millennium, London, UK. (Poster)
Synthetic chemistry
Baker, A., Graz, M., Saunders, R., Evans, G. and Wirth, T. (2013)
Synthesis of Di- and Trisulfides using Flow Reactors
Presented at the 12th International Conference on Selenium and Tellurium, Cardiff, UK (poster)
Baker, A., Graz, M., Saunders, R., Evans, G. and Wirth, T. (2013)
Synthesis of Di- and Trisulfides using Flow Reactors
Presented at the 2nd SCi/RSC Symposium on Continuous Processing and Flow Chemistry, Horsham, UK
Bioanalysis
Thabit Jones, A., Graz, M and Oldham, H (2017)
Quantitative analysis of an oil based natural compound extracted from plasma
ICMAN-IUPHAR, Aberdeen, UK (Poster and oral presentation)
Drug development studies
Oldham, H. (2017)
Drug Development with natural products – A journey
ICMAN-IUPHAR, Aberdeen, UK 
Oldham, H. (2017)
Drug metabolism studies with natural products – A journey
46th Drug Metabolism Discussion Group Open Meeting, Cambridge, UK
Oldham, H. (2017)
P1b - Drug metabolism studies with natural products
46th Drug Metabolism Discussion Group Open Meeting, Cambridge, UK
Mootral
Graz, M., Vrancken, H., Riede, O. and Brandsma, M. (2017)
The effect of a blend of natural compounds (NX-RH-201) on the quality of milk produced ona cpmmercial farm under normal operational conditions
International Dairy Federation Summit, Ireland (poster)